Clinical Pharmacology by Peter N. Bennett & Morris J. Brown & Pankaj Sharma
Author:Peter N. Bennett & Morris J. Brown & Pankaj Sharma [Bennett, Peter N.]
Language: eng
Format: epub
ISBN: 9780702051135
Publisher: Elsevier Health Sciences UK
Published: 2012-07-30T00:00:00+00:00
Prolactin increase
Classical antipsychotics raise plasma prolactin concentration by blocking dopamine receptors in the tuberoinfundibular pathway, causing gynaecomastia and galactorrhoea in both sexes, and menstrual disturbances in women. A change to an atypical agent such as aripiprazole, quetiapine or olanzapine (but not risperidone or amisulpride) should minimise the effects. If continuation of the existing classical antipsychotic is obligatory, dopamine agonists such as bromocriptine and amantadine that reduce prolactin secretion may help.
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